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Cover of Cilia

Cilia

model organisms and intraflagellar transport

By Stephen M. King,Gregory J. Pazour

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Publish Date

2009

Publisher

Elsevier Academic Press

Language

eng

Pages

390

Description:

"Cilia are highly conserved organelles that serve motile and/or sensory functions. These organelles power cell movement, generate fluid flow in various organs, act as sensors of the extracellular environment and have been modified for various specialized tasks such as light reception and smell. Defects in these ubiquitous organelles lead to a broad array of human genetic disorders that range from polycystic kidney disease, retinal degeneration, epilepsy and infertility to developmental defects such as situs inversus and polydactyly. This volume is the third in a three-part series on cilia that focuses on the use of model organisms to gain insight into ciliary function and on the process of intraflagellar transport (IFT) that is essential for the assembly and maintenance of ciliary structures."--Publisher's description.