An edition of The Philadelphia chromosome (2013)
The Philadelphia chromosome
a mutant gene and the quest to cure cancer at the genetic level
By Jessica Wapner
Publish Date
2013
Publisher
The Experiment, LLC,Distributed by Workman Pub. Co.,The Experiment
Language
eng
Pages
303
Description:
This work discusses the history of a genetic mutation, discovered in 1959, that causes chronic myeloid leukemia, and traces the research and breakthroughs that led to the creation of a drug that makes this once-fatal illness now treatable. It focuses on what is widely viewed as the 'poster child' of rational drug development in the cancer research world. The history of the founding of a genetic mutant chromosome in the indication of Chronic myeloid leukemia disease, and the subsequent development of "Gleevec," is the keynote of this publication.
subjects: Mutation (Biology), Genetic aspects, Imatinib, Cancer, Chronic myeloid leukemia, History, Research, Gene therapy, Chronic diseases, Leukemia, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Philadelphia Chromosome, Fusion Proteins, bcr-abl, Genetic Therapy, Myeloid Leukemia, Genetics, Therapy, Medical care, united states, Chronisch-myeloische Leukämie, Gentherapie
People: David S. Hungerford (1938-)