Immunobiology of bacterial CpG-DNA

Description:

Bacterial CpG-DNA sequences not only serve for genetic information but act as "danger" signal to alert immune cells such as macrophages & dendritic cells. CpG-DNA directly causes activation of these members of the innate immune system yielding in up-regulation of co-stimulatory molecules & pro-inflammatory cytokines. As such they act as "natural" adjuvants to promote protective Th1 polarized T cell immune responses. This book is the first comprehensive review of the data emerging in this field.

subjects: Immuno competent cells,  Antigen-Presenting Cells,  Immunology,  Cellular immunity,  CpG Islands,  T cells,  DNA Vaccines,  Antigen presenting cells,  Immunologic Adjuvants,  Immune response,  Bacterial DNA,  Immunocompetent cells